The aim of any drug administration therapy is to alleviate symptoms of a condition, (e.g. We take Aspirin to get rid of a headache), or to eliminate the causes of an illness (e.g. We take antibiotics to treat a bacterial infection). To achieve this the person responsible for the administration will determine a dosage which will achieve the desired effect. More Information

Pump Therapy and Asthma.

AMT products are employed only in a specialised area of Asthma therapy. Asthma is a common condition frequently related to various allergies, and unfortunately with apparently increasing frequency.

In these pages we will only address those limited areas where we have a direct interest. However we have also researched the Internet resources in this field, and have provided a number of links which we hope will be found useful for those interested in this general topic.

We have also included a page which explains why Pumps, which provide a continuous infusion, may offer benefits over more conventional intermittent injections.

There are, at present, two pioneering centres in the UK who are using pumps to provide continuous subcutaneous infusion of Terbutaline (Bricanyl) as a means to control some extremely difficult cases of asthma. To provide a professional overview of this application we have had permission to reproduce a published article which discusses the control of Brittle Asthma and refers to the use of infusion pumps in this area.

Our infusion products are widely used in this area and there is a wide choice to suit individual patient requirements. Products of particular benefit in this therapy are Saflo™
Saflo™ Needle Safe Subcutaneus Infusion Set
and Saflo™ 90
Saflo™ 90 Needle Safe Subcutaneus Infusion Set
needle safe infusion sets, the Medtronic Silhouette
Silhouette Infusion Sets
or Quick-Set Infusion Sets
Quick-Set Infusion Sets
and the Neria™ Soft
Neria™ Soft Infusion Sets
range of products.

The special feature of these sets is that they use soft teflon connections in place of conventional needles. These are much more comfortable for the individual, and significantly reduce the problems of allergic reaction at the infusion sites. This provides an opportunity for long term infusion to make this therapy effective.

The Crono
Cane Crono Infusion Pump
and Crono 30
Cane Crono 30 Pump
pumps are widely used in this application.

Primary Immunodeficiency (PID)

With the recent introduction of Immunoglobulin drugs licenced for subcutaneous infusion there has been created a need for a suitable device for the delivery of these drugs. The viscous nature of these drugs, and the fast infusion times currently required, are a challenge to current pump technology, and the Super PID pump has been specifically developed to meet this requirement.

Main Relevant Products: Crono Super PID
Cane Crono Super PID Pump
, Crono S-PID 30
Cane Crono S-PID 30 Pump
, Crono S-PID 50
Cane Crono S-PID 50 Pump
, Crono Twin
Cane Crono Twin Pump
. Neria range of needle sets, Saflo™ 90
Saflo™ 90 Needle Safe Subcutaneus Infusion Set
.

Oncology

There is widespread use of portable infusion devices for the administration of therapeutic agents in Oncology. Continuous infusion of these drugs, as opposed to large bolus injections, enables them to be employed more effectively, whilst helping to minimise some of the extreme side effects that may occur.

Main Relevant Products: Crono SC 50
Cane Crono SC 50 Pump
.

Pain Relief Medication

The most common application in this area is the continuous administration of Diamorphine as a means to control pain, frequently associated with end stage cancer therapy. Most usually pumps like the McKinley T34 are employed in this area, but where portability is an important factor the Crono
Cane Crono Infusion Pump
, Crono 30
Cane Crono 30 Pump
and the Crono SC
Cane Crono SC Pump
pumps can be of benefit.

Hormone Therapy

Pumps have been employed in the area of fertility control for some time but this appears to be diminishing now. The most frequent applications have been the use of GnHRH and LHRH infusions. A particular requirement for pumps in this area is for drugs to be administered as pulses at fixed intervals, typically 90 minutes, to mimic the normal Hormone release mechanisms.

The recent introduction of the Crono P
Cane Crono P Pump
pump, however, may well broaden the range of applications.

Rehydration

More recently we have become aware of the use of subcutaneous infusion to provide a route for medium volume rehydration. This has been developed to avoid the need to use the more conventional Intravenous route in areas where there may not be the appropriate clinical support, for example in Nursing Homes. This therapy is termed HYPODERMOCLYSIS.

Main Relevant Products: Saflo™ 90
Saflo™ 90 Needle Safe Subcutaneus Infusion Set
.

Parkinsons Disease

The continuous subcutaneous infusion of Apomorphine is used in the treatment and support of this condition.

Main Relevant Products: Neria™
Neria™ Infusion Sets
, Saflo™ 90
Saflo™ 90 Needle Safe Subcutaneus Infusion Set
.

Addison's Disease

Exciting new work on pulsatile cortisol for Addison's Disease is being performed using the Crono P pulsatile infusion pump. The primary researchers working on it are Georgina Russell and Stafford Lightman in Bristol. The following links will provide more information on this.

Subcutaneous pulsatile glucocorticoid replacement therapy. More Information

Cardio-metabolic consequences of glucocorticoid replacement: relevance of ultradian signalling. More Information

Subcutaneous pulsatile glucocorticoid replacement therapy. More Information

Main Relevant Products: Crono P
Cane Crono P Pump
, Quick-Set Infusion Sets
Quick-Set Infusion Sets
.

Site Developement

These are areas of therapy where there is little information readily available. We would welcome any contributions which provide additional information on these topics, which we will publish and/or link to from these pages. Please email us if you have something you would like to contribute.